Laine Lab

Sorbonne University

Ile-de-France (FR1) · France

ERC-funded
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Research focus

ERC Consolidator Grant · 2022

Proteome diversification in evolution

Proteins are essential and incredibly versatile actors for all biological processes in living organisms. Massive amounts of data describing their amino acid sequences and 3D shapes are now openly accessible. Yet, we still know little about how they interact and function with one another in vivo. Nor how they diversified throughout evolution to orchestrate highly specialised behavioural traits. This ERC CoG proposal, PROMISE, meets the urgent need for decrypting protein sequences and structures toward guiding biological intervention. It will assess and harness the protein variations naturally occurring in multi-cellular organisms to unlock critical questions across developmental,…

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