ERC Consolidator Grant · 2022
ADPribosylation and Ubiquitination; post-translational interplay
Post-translational modification of proteins is essential in regulating proper cellular homeostasis. The attachment and removal of the small protein Ubiquitin (Ub) is amongst others involved in regulating immune response, cell cycle progression and proteasome mediated protein degradation. The (de)conjugation of adenosine-di-phosphate ribose (ADPr) on the other hand is essential in regulating DNA damage responses and apoptosis. ADPribosylation and ubiquitination both dictate a highly complex signaling code and intriguingly these two PTM systems also communicate, as Ub was recently found to be ADPribosylated on multiple different positions. This new layer of controlling ubiquitination plays…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.