ERC Starting Grant · 2022
The molecular nexus coupling Cell Metabolism to Cell cycle and Genome Surveillance
Metabolic fluctuations and changes in DNA replication and cell cycle dynamics orchestrate early development and tumorigenesis. Of particular interest are reactive oxygen species (ROS), by-products of basal metabolic reactions, and major signaling molecules driving cell proliferation, differentiation, and cancer cell growth. However, despite their utmost importance in cell physiology, how ROS signals communicate to the cell cycle and genome safeguard mechanisms remains poorly explored. My postdoctoral work has illuminated this topic by discovering novel redox-sensitive mechanisms that directly couple metabolic nucleotide fluctuations and oxygen starvation to DNA replication dynamics. These…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.