ERC Advanced Grant · 2023
Ubiquitylation is an essential posttranslational modification that governs the activities and interactions of cellular proteins. The structural diversity of polyubiquitin chains, collectively called the ‘ubiquitin code’, is thought to determine the fate of the modified proteins. Although many analytical and inhibitory ubiquitin-specific reagents exist, we lack the tools to create polyubiquitin chains of defined linkage on a protein of interest in cells to investigate their signalling functions. We recently established a method to induce substrate-specific polyubiquitylation via three major linkages, M1, K48, and K63. Based on this technology, we now propose to develop a new generation of…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.