ERC Advanced Grant · 2023
Genome topology and mechanical stress
The nucleus is the stiffest organelle in the cell and is constantly challenged by intrinsic and extrinsic forces that deform the nuclear envelope. Chromosomes are mechanical objects that can sense, transduce and adsorb mechanical forces. Inter-chromosomal contacts and nuclear envelope-associated domains contribute to transduce mechanical stress when cells experience compression, stretching or interstitial migration. We aim to study the mechanical properties of the chromosomes and how genome integrity and the chromatin topological landscape are affected by nuclear deformations. We will combine mechanistic, genetic and genomic studies in yeast (WP1) with genomic, imaging and microfluidic…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.