ERC Advanced Grant · 2023
REVisiting Antibody structures and repertoires through advances in Mass spectrometry and Proteomics
In REVAMP, I will create innovative structural mass spectrometry (MS) and proteomics techniques to generate an unprecedented molecular understanding of the diversity and structural and functional characteristics of human antibody repertoires. These repertoires are highly personal and play a key role in our human immune response. Recently, my research has taken a novel challenging avenue, with a focus on the development of cutting-edge MS-based techniques to better understand antibody structure and function. With these methods, I have started to monitor at the protein level (changes in) endogenous antibody repertoires with clonal resolution, including those induced by antigen-specific…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.