ERC Advanced Grant · 2023
Unraveling the Supramolecular Architecture of Molecular Machineries in Adaptive Immunity
To combat daily threats of pathogens and abnormal cells, the human organism features a sophisticated defense mechanism called the adaptive immune system. In broad terms, this intricate mechanism is triggered by specific peptide epitopes presented on molecules of the major histocompatibility complex class I (MHC I), which are scanned by cytotoxic T cells. Intracellular transport, loading, and cell-surface recognition of antigenic peptides on MHC I are orchestrated by machineries, the peptide-loading complex (PLC) and the T cell receptor (TCR) complex. The PLC is composed of multiple subunits, including the antigen translocation unit TAP, the MHC I heterodimer, and several chaperones ensuring…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.