ERC Consolidator Grant · 2023
Tuning TDP-43 self-assembly to understand physiological function and dysfunction
Neurodegenerative disorders are an enormous societal burden and we lack therapies that target these diseases at their origins. To develop therapies, we need to understand what goes wrong at the molecular level. I uncovered key mechanisms that cause RNA-binding proteins, such as TDP-43, to dysfunction and drive neurodegenerative processes. I discovered that RNA-binding proteins self-assemble into ribonucleoprotein granules that are the likely origins of RNA-binding protein aggregates. More recently, my group and I revealed aberrant phase transitions of condensed RNA-binding proteins occurring in disease and identified fundamental mechanisms by which such phase transitions are regulated in…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.