ERC Consolidator Grant · 2023
Elucidating the role of biomolecular condensation in meiotic DNA double-strand break formation
Meiosis universally relies on the formation of DNA double-strand breaks (DSB) to initiate a genome-wide recombination program that promotes genetic diversity and is required to produce chromosomally-balanced haploid gametes. DSB formation is catalyzed by Spo11, which in acts in conjunction with nine essential partners in yeast, including the RMM proteins. We previously found that RMM undergoes DNA-dependent condensation, and proposed that this organizes intracellular sub-compartments within which controlled DSB formation takes place. The RMM proteins connect DSB formation to chromosome structure, and are subject to overlapping regulatory pathways that control the timing, position, and…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.