Wagner Lab

French Alternative Energies and Atomic Energy Commission

Ile-de-France (FR1) · France

ERC-funded
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ERC Consolidator Grant · 2023

An anaerobic native approach to shine Light on C1-cycling biochemistry using Environmental microbial biomass.

Microorganisms have shaped the Earth's biogeochemistry for almost 4 billion years. Among them, anaerobic archaea dominate the carbon one-unit cycle, nourish ecosystems, and orchestrate the final step of organic matter degradation. They remain mainly uncharacterised and uncultured while harbouring a universe of concealed enzymatic chemistry, which cannot be approached via classic omics. EnLightEn will study these non-isolated archaea as part of the "microbial dark matter" by exploiting native biomass rather than artificial systems. The overall carbon-processing catabolic landscape will be pictured through an anaerobic pipeline, simultaneously investigating multiple enzymes bound to…

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