ERC Consolidator Grant · 2023
Deconstruction of complex crosslinking damage
Cells are constantly challenged by complex crosslinking damage, which is caused not only by endogenous metabolites, such as reactive aldehydes, but also by various exogenous sources. While crosslinking damage to DNA has been studied extensively, almost all reactive agents act pleiotropically and also damage RNA and proteins. However, due to the complexity of the damage, it is difficult to determine which components of the damage are responsible for specific cellular outcomes. Therefore, it is unknown how crosslinking damage to RNA and proteins affects cellular homeostasis and how it is detected and resolved. Here, I propose to exploit novel experimental model systems that deconstruct…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.