ERC Consolidator Grant · 2023
The gene expression patterns that define specific cell types are determined in part by epigenetic information encoded in histone marks that guide chromatin organization. During chromosome duplication, new histones lacking this information must be deposited to support the doubling of chromatin. However, the molecular mechanism of histone deposition and the coordination pathways that ensure epigenetic information is transmitted remain unknown. Determining the mechanics of chromosome assembly promises to open a new frontier in our understanding of the propagation of cell fate decisions that support multicellular life. Due to the antiparallel configuration of DNA, different DNA synthesis…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.