ERC Starting Grant · 2023
A perfect macromolecular structure would provide an all-atom description of the molecule, including not only the well-ordered polypeptide or polynucleotide framework but all other species: metals and other ions, cofactors, lipids, substrates and inhibitors. However, current structural data include no or very little information on elemental composition, leading to significant errors and omissions in atomic models. To address this issue, I propose to develop a method, Reconstructed Electron Energy Loss - Elemental Mapping (REEL-EM), that will map elemental distribution within macromolecular complexes by bringing together well-established principles in analytical electron microscopy (EM) and…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.