ERC Starting Grant · 2023
Mechanisims of nuclear self-assembly
Shape and function of the vertebrate nucleus depend on the choreographed interplay between lipids, proteins, and DNA to form the nuclear envelope. Even small molecular changes, such as point mutations in the proteins of the nuclear envelope (the lamina) cause detrimental human diseases including premature aging, cancer, and heart disease. To date, a clear, mechanistically compelling explanation for the dynamic coupling of lipids, proteins, and DNA to safeguard nuclear shape and function is still missing. We here propose to build minimal, synthetic nuclei (‘Organelloids’) bottom-up as a tool to study the self-assembly of a functional nucleus. We recently discovered the conserved molecular…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.