ERC Starting Grant · 2023
NTase Products and Cyclic Nucleotide Signalling
Survival of a cell depends on its ability to receive and process information coming from the environment. Second messengers are the key transmitters of information that rapidly amplify the signal inside the cell. Cyclic nucleotides (CNs) are the most diversified category of second messengers and are found in all organisms modulating diverse pathways. CNs are best studied in bacteria, where they have a variety of biological functions. In humans, the only described cyclic di-nucleotide is cGAMP, which elicits an antiviral immune response. cGAMP is rapidly emerging as a promising drug candidate in e.g., cancer immunotherapy. I hypothesise that additional CNs contribute to yet uncharacterized…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.