ERC Starting Grant · 2023
Mechanisms of Kaposi's sarcoma herpesvirus replication and maintenance during latency
Oncogenic viruses are the third most common cause of cancer in humans. Kaposi’s sarcoma herpesvirus (KSHV) is an oncogenic virus that establishes life-long latent infection and can drive tumor development in immunocompromised individuals. To date no definitive treatment against KSHV has been developed and KSHV-derived cancers are uncurable. Despite the advances in understanding KSHV biology, many key aspects are still obscure, and detailed mechanistic studies are needed for the development of rational targeted therapies. During latency, KSHV exploits the host cell’s replication and segregation machineries to faithfully copy and transmit its genome during cell division. Which cellular…
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