ERC Advanced Grant · 2024
CONNECTING VOLTAGE-GATED POTASSIUM CHANNELS TO TRANSCRIPTIONAL AND TRANSLATIONAL REGULATION
Potassium (K+) channels are found in the majority of cells in almost every organism, where they regulate a wide variety of physiological functions in response to environmental stimuli. The goal of TRANSION is to confirm our hypothesis that physical coupling between voltage-gated potassium (K+) channels in the Shaker-type (Kv1) family and specific transcription factors (TFs) provides a widespread signaling checkpoint that coordinates information from different stimuli and orchestrates appropriate transcriptional and translational responses. This ground-breaking program will reveal novel roles for ion channels in regulating signal transduction, changing the paradigm by which cells adjust…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.