ERC Advanced Grant · 2024
Complex I (NADH:ubiquinone oxidoreductase), one of the largest membrane-bound enzymes in the mammalian cell, uses the reducing potential of NADH to drive protons across the inner mitochondrial membrane and power ATP synthesis. It is a keystone of metabolism, crucial for survival of human cells, and a primary site of mitochondrial dysfunctions and clinical disease. Complex I is also an efficient energy-converting biomachine, which shares conserved subunits, a molecular architecture, and modular design with prokaryotic type-4 hydrogenases, such as formate hydrogenlyase (FHL), that contribute to microbial H2 metabolism and geochemical cycles. Detailed cryo-electron microscopy (cryoEM)…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.