ERC Advanced Grant · 2024
MIM pores: composition, structure and function
Mitochondria are double-membrane organelles involved in key biological processes such as metabolism, calcium homeostasis and cell death. A major role of mitochondria in inflammation, a mechanism of innate immunity against tissue damage, has been recently recognized. Due to their proteobacterial origin, certain mitochondrial matrix contents can act as potent immune agonists when exposed to the cytosol. Hence, knowing the dynamics and molecular architecture of the mitochondrial pores mediating the release of these mitochondrial contents is crucial for understanding the role of mitochondria in inflammation. While in apoptosis BAX and BAK proteins form pores at the mitochondrial outer membrane…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.