ERC Consolidator Grant · 2024
Molecular interconnections between transcription, translation and DNA repair in bacteria
This proposal brings together the fields of bacterial transcription, translation and DNA repair with state-of-the art single-molecule biophysics in vitro and in vivo, biochemistry and structural biology to address a central but understudied question in biology: how are different macromolecular processes interconnected and functionally coupled? I aim to elucidate this by investigating the crosstalk between central processes in bacterial gene expression: transcription, translation and DNA repair. First, to understand what determines whether transcription is coupled to translation, we will reconstitute the complete transcription-translation system in vitro and image the process in real-time…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.