Erdel Lab

Research focus

ERC Consolidator Grant · 2024

Reshaping the nucleome to reveal its gene- and mechano-regulatory function

The content of the cell nucleus is highly organized at different levels. Chromatin is partitioned into domains that carry different post-translational histone modifications, and it exhibits a multiscale structural organization from small loops to large compartments. Nuclear RNAs and proteins recognize cues on chromatin, forming different types of chromatin-associated complexes and condensates. The nucleus as a whole is the largest and stiffest organelle of the cell and modulates its mechanical properties. Dysregulation of the nucleome at any level goes along with altered gene- and mechano-regulation in diseases such as metastatic cancers. Currently, the functions of the different…

From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.