ERC Consolidator Grant · 2024
Novel Human Chaperone Mechanisms Counteracting Protein Misfolding and Aggregation in the Cell
MolecuMolecular chaperones are vital for maintaining proteostasis by protecting our cells from the deleterious effects of protein misfolding and aggregation. The diverse ~50-chaperone J-domain protein (JDP, Hsp40) family acts as cells’ first line of defense, binding and remodeling non-natively folded proteins and facilitating their transfer to downstream chaperones. Recent discoveries from our lab have shown that JDP function is far more complex than previously described - identifying both a novel mode of regulation by which DNAJB1 coordinates amyloid disaggregation, and a new mechanism by which class A JDPs recognize destabilized proteins. Based on these findings and the sheer diversity of…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.