ERC Starting Grant · 2024
The mitochondrion of the malaria agent Plasmodium falciparum is critical for parasite survival and a confirmed drug target. The dynamic organelle undergoes a Plasmodium-specific membrane remodelling process to adapt to changing metabolic conditions in different hosts. This remarkable transformation is thought to be driven by the arrangement of divergent ATP synthase and respiratory chain complexes into supramolecular assemblies, which shape the internal cristae membranes. However, the structures of both oxidative phosphorylation (OXPHOS) protein complexes and the underlying molecular mechanism are unknown. Having recently pioneered parasite OXPHOS complex structure determination, I will…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.