ERC Starting Grant · 2024
Antimicrobial resistance is on target to become the leading cause of death by 2050. A major determinant of resistance in Gram-negative bacteria is the tripartite cell envelope, which forms a physical barrier to drugs. Understanding how this structure is made, therefore, is of critical importance. Despite this, how the lipids that make the cell envelope are delivered remains poorly understood. Recently, a family of proteins has emerged that likely holds the key to understanding these lipid transport mechanisms. The DedA family of membrane proteins is conserved across all domains of life and early evidence suggests they are central to lipid transport, antimicrobial sensitivity, and virulence…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.