ERC Starting Grant · 2024
Illuminating human Fe-S cluster biology
Iron-sulfur (Fe-S) clusters were ancient partners in the origin of life- spontaneously formed in the anaerobic primordial oceans, they likely helped catalyze carbon fixation and rudimentary metabolism. Highly versatile, Fe-S clusters unlock previously inaccessible abilities for their binding proteins, aiding in electron relay, catalysis, regulation, and structural stability. Over the past 20 years, it has become clear that Fe-S clusters must be formed de-novo within the cell by essential proteinaceous machineries and relayed directly to their binding proteins. During this time, huge strides have been made to delineate the components and molecular mechanisms of this pathway. However, our…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.