Petryk Lab

Research focus

ERC Consolidator Grant · 2025

REVEALING THE MECHANISMS LINKING GENOME REPLICATION AND EPIGENOME MAINTENANCE

DNA replication is essential for transmitting genetic information across cell divisions. Beyond DNA duplication, eukaryotic DNA replication forks must coordinate diverse processes necessary for the genome integrity maintenance, preservation of chromatin structure, and inheritance of epigenetic information contained within chromatin. DNA replication forks must perform these diverse tasks in real-time across various chromatin states and physiological conditions. To achieve coordination of these processes, many factors play pleiotropic roles, simultaneously regulating DNA synthesis with epigenome maintenance. Furthermore, the leading and lagging strands of the fork are replicated by distinct…

From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.