ERC Consolidator Grant · 2025
Mechanisms of precursor mRNA fate control
Messenger RNA (mRNA) is critical for transferring information from DNA to protein, a process that requires a series of tightly orchestrated steps. During these steps, mRNAs are classified as either functional or faulty, and directed towards biogenesis or degradation. This ensures the efficient and faithful expression of protein-coding genes. Yet, the mechanisms that decide the fate of mRNAs remain unclear. Prior work and our preliminary data show that RNA splicing plays a critical role in making this decision, by committing functional mRNAs towards packaging into ribonucleoprotein complexes (mRNPs) and directing faulty mRNAs towards degradation. Although recent studies have revealed…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.
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