ERC Consolidator Grant · 2025
Elucidating the Role of Subcellular GPCR Nanoswitches in Signaling Specificity
G protein-coupled receptors (GPCRs) relay extracellular information across the cell membrane to mediate most physiological cell functions. Many cell-surface GPCRs stimulate the production of cyclic adenosine monophosphate (cAMP), a diffusible second messenger, to elicit receptor-specific, long-range cell functions. However, given the mobility of second messengers, this canonical model fails to explain receptor-specific functions across multiple GPCRs that signal via cAMP. This application proposes that GPCRs, in dramatic contrast to the second messenger concept, form highly-localized, nanometer-size cAMP signaling units at various subcellular locations, i.e. subcellular GPCR nanoswitches.…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.