Boumendil Lab

Research focus

ERC Starting Grant · 2025

Nuclear pores and chromatin organization: a crosstalk?

Chromatin organization plays a crucial role in regulating DNA-related processes such as transcription, replication, and repair. In most somatic cells, heterochromatin localizes at the nuclear periphery while euchromatin is broadly distributed within the nucleus. This spatial organization is believed to mostly rely on the association of heterochromatin with the nuclear lamina, which in turn participates in gene repression. In a striking contrast, the nuclear pore vicinity is always devoid of heterochromatin, therefore forming heterochromatin exclusion zones within the heterochromatin layer of the nuclear periphery. In rupture with the classical view that the nuclear lamina stands as the main…

From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.