ERC Starting Grant · 2025
Centrosome Reduction: The elusive culprit behind unexplained male infertility?
Worldwide, 17% of couples are affected by infertility, with studies showing a steady decline in sperm quality over recent decades. One in three cases remain unexplained, often marked by a sudden loss of the early embryo due to erroneous cell division, and are therefore hard to treat. Case studies link early embryonic loss to defects in the sperm centrosome, a paternally inherited organelle essential for the embryo's first cell division. Unfortunately, a mechanistic understanding of sperm centrosome function is lacking and its contribution to (in)fertility is understudied. CentRed is centred on the hypothesis that the sperm centrosome is remodelled during spermatogenesis to organise the…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.